Analyzing the Surge of Influenza A/H3N2 and the Strategic Role of Vaccination

Epidemiologists have noted a significant uptick in Influenza A cases during the year-end season, with the H3N2 strain being the primary driver. This trend stems from both social behaviors and specific viral characteristics.

1. Factors Driving the Outbreak

  • Increased Mobility: Holiday gatherings and heightened travel facilitate the rapid transmission of respiratory viruses in crowded or enclosed environments.

  • Immunity Gap: Due to limited natural exposure to H3N2 in recent years, population-wide immunity has waned, leaving a larger segment of the public susceptible to infection.

  • Viral Adaptation: H3N2 excels at adhering to and replicating within the upper respiratory tract. While its virulence remains stable, seasons dominated by this strain typically see higher hospitalization rates, particularly among seniors and young children.

2. The Efficacy of Immunization

Current medical data confirms that quadrivalent vaccines (covering H1N1, H3N2, and two Influenza B lineages) provide robust defense:

  • Reducing Severity: Clinical evidence shows vaccination reduces hospitalization risks by 27% to 46% and significantly lowers the likelihood of organ failure or the need for mechanical ventilation.

  • Immune Response Timeline: It typically takes two weeks post-vaccination for the body to develop full protective immunity.

  • Annual Necessity: Because flu viruses mutate constantly and antibody levels diminish over time, annual boosters are essential to maintain effective protection.

Source: https://tuoitre.vn/cum-a-h3n2-bung-phat-tiem-vaccine-cum-la-la-chan-phong-benh-hieu-qua-20251226141913727.htm

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