Breakthrough in transforming fossil fuel derivatives into premium pharmaceutical precursors

Researchers at Peking University, led by Professor Jiao Ning, have unveiled a novel chemical method to elevate the value of coal-derived compounds. This study, published in the journal Nature in March 2026, resolves a technical challenge in organic chemistry that has persisted for over 150 years.

Key technical highlights of the invention include:

  • Bond structural transformation: The new method enables the efficient conversion of olefins (low-cost double-bonded compounds produced on a large scale from coal and petroleum) into alkynes (high-value triple-bonded compounds).

  • Reaction condition optimization: Unlike previous complex and harsh processes, this technology operates under “milder” conditions, enhancing yield and reducing energy costs for industrial production.

  • Leveraging domestic resources: In China, olefins can be synthesized from coal via a methanol intermediate. This invention optimizes abundant coal reserves to produce sophisticated compounds for pharmaceuticals and advanced materials, reducing over-reliance on imported oil.

  • Economic impact: The commercialization of this technology promises to restructure the chemical industry value chain, allowing for the production of medicinal raw materials at more competitive costs while strengthening raw material supply autonomy.

While further time is required for industrial-scale deployment, experts view this advancement as a positive signal in applying modern chemistry to optimize natural resources.

Source: https://cafef.vn/phat-minh-cua-trung-quoc-lam-rung-chuyen-nganh-duoc-pham-bien-than-da-thanh-nguyen-lieu-thuoc-chua-benh-hieu-qua-cao-nhung-chi-phi-thap-188260325165230415.chn

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